Dousing fire with gasoline: interplay between lysosome damage and the NLRP3 inflammasome
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2 3 4 5 6 7 8 9 10 Dousing fire with gasoline: interplay between lysosome damage 11 and the NLRP3 inflammasome 12 13 Joel D. Schilling 14 15 16 17 18 19 20 21 Diabetic Cardiovascular Disease Center, Department of Medicine, Department of 22 Pathology and Immunology, Washington University School of Medicine, St. Louis, 23 Missouri, 63110 24 25 To whom correspondence should be addressed: Joel D. Schilling, M.D., Ph.D. 26 Diabetic Cardiovascular Disease Center, Washington University School of 27 Medicine, St. Louis, MO 63110, E-mail address: [email protected] 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 Articles in PresS. Am J Physiol Cell Physiol (June 15, 2016). doi:10.1152/ajpcell.00174.2016
منابع مشابه
Dousing fire with gasoline: interplay between lysosome damage and the NLRP3 inflammasome. Focus on "NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx".
SINCE ITS DISCOVERY over a decade ago, the NLRP3 inflammasome has been the focus of intense investigation. Although much has been learned about the molecular regulation of this potent inflammatory complex, there are several unanswered questions about what drives its assembly. At its simplest, the inflammasome is a cytosolic complex of proteins that functions to cleave and release the cytokines ...
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تاریخ انتشار 2016